Critical Thinking

The octanol-water
partition coefficient (logKow) is an important parameter when assessing the
environmental fate of pharmaceuticals. Values of logKow indicates a compounds
ability to partition between an organic and an aqueous phase, and therefore can
indicate a compounds solubility. A high Kow value denotes hydrophobicity and a
low Kow denotes hydrophilicity (Miller et al., 1985).

The ERA specifies that following phase I analysis, if a compound with a logKow
below 4.5 should progress to screening in phase II due to its potential to bioaccumulate
(EMA, 2006).  

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